Abstract : Objectives: To investigate whether the cytotoxic effect of Cimicifuga rhizoma extract is associated with cell death in the human keratinocyte (HaCaT) and human melanoma cell lines (G361). Methods: Apoptosis induced by Cimicifuga rhizoma extract was confirmed by water-soluble tetrazolium salts-1 (WST-1) assay, immunocytochemistry, and western blot. Additionally, the release of cytochrome c and apoptosis-inducing factor (AIF) was visualized by confocal laser scanning microscopy.Results: The results showed that Cimicifuga rhizoma extract significantly reduced the viability of G361 cells with half-maximal inhibitory concentration (IC 50) of 200 μg/ml, and the apoptotic process was found to occur via the activation of caspase-3 and caspase-9 pathways. Besides, the release of cytochrome c and AIF was also detected. Conclusions: This study suggests that Cimicifuga rhizoma extract causes apoptosis of human melanoma cells through the intrinsic apoptotic pathway.
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Abstract : Objectives: This study aimed to investigate factors related to the periodontal health of 12-year-old children. Methods: In 2015, the Korean Children's Oral Health Survey from the Ministry of Health & Social Welfare conducted a nationwide representative sample comprised of 23,702 12-year-old children. The calibration-trained dentists examined the gingivitis and dental calculus of the children taking into consideration of the Löe and Silness gingival index to diagnose gingivitis with a modified gingivitis scale. We used questionnaires to collect data from the children on dental treatments, the experience of dental pain and gingival bleeding, self-perceived oral health, and oral health behaviors. Data were analyzed using a complex samples Chi-square test, general linear model, and logistic regression. Significance was determined at P
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Abstract : Objectives: Dentists and dental hygienists undergo high levels of stress due to various factors and the burnout of health-care personnel is very important in the context of personal and social problems. Therefore, empirical research reflecting the social, cultural, and special circumstances of the medical environment is necessary. Here, we explore the causes and outcomes of burnout in dentists and dental hygienists and present ways to prevent burnout.Methods: A cross-sectional research design was used to measure burnout of 141 dentists and 61 dental hygienists. A structured questionnaire containing the Maslach Burnout Inventory (MBI) was administered from May to June, 2018. Data were analyzed using SPSS 25.0, descriptive statistics, t-test, Mann-Whitney test, Kruskall-Wallis test, and multiple regression analysis.Results: Each participant’s MBI was measured in three aspects (emotional exhaustion, depersonalization, and personal accomplishment). The MBI scores of dentists with regards to their emotional exhaustion, depersonalization, and personal accomplishment were 24.8%, 34%, and 48.2%, respectively. Alternatively the scores of dental hygienists were 45.9%, 44.3% and 52.5%, respectively, for the same parameters. While the factors affecting the burnout of dentists and dental hygienists were different, it had a negative impact on the professional performance of both.Conclusions: According to the results of this study, Korean dentists and dental hygienists experience high levels of work-related burnouts. This can have adverse impacts on their personal health and that of their patients. Therefore, stress management is necessary in dentists and dental hygienists.
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Abstract : Objectives: The primary objective of this study was to determine if the number of missing teeth could be predicted by oral disease pathogens, and the secondary objective was to assess whether deep learning is a better way of predicting the number of missing teeth than multivariable linear regression (MLR). Methods: Data were collected through review of patient's initial medical records. A total of 960 participants were cross-sectionally surveyed. MLR analysis was performed to assess the relationship between the number of missing teeth and the results of real-time PCR assay (done for quantification of 11 oral disease pathogens). A convolutional neural network (CNN) was used as the deep learning model and compared with MLR models. Each model was performed five times to generate an average accuracy rate and mean square error (MSE). The accuracy of predicting the number of missing teeth was evaluated and compared between the CNN and MLR methods. Results: Model 1 had the demographic information necessary for the prediction of periodontal diseases in addition to the red and the orange complex bacteria that are highly predominant in oral diseases. The accuracy of the convolutional neural network in this model was 65.0%. However, applying Model 4, which added yellow complex bacteria to the total bacterial load, increased the expected extractions of dental caries to 70.2%. On the other hand, the accuracy of the MLR was about 50.0% in all models. The mean square error of the CNN was considerably smaller than that of the MLR, resulting in better predictability. Conclusions: Oral disease pathogens can be used as a predictor of missing teeth and deep learning can be a more accurate analysis method to predict the number of missing teeth as compared to MLR.
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Abstract : Objectives: The purpose of this study was to investigate the association between the components of metabolic syndrome (MetS) (waist circumference, hyperglycemia, hypertriglyceridemia, low levels of high-density lipoprotein cholesterol, and hypertension) and periodontitis in Korean adults aged 35-79 years. Methods: In this study, data from the Sixth Korean National Health and Nutrition Examination Survey (KNHANES, 2013-2015) were analyzed. Among the 22,948 participants of the Sixth KNHANES, 8,314 participants, who were aged 35-79 years and had completed all systemic and oral health examinations and questionnaires, were included in this study. Confounding variables associated with the demographics and socioeconomic status and systemic and oral health-related behaviors were age, gender, household income, the educational level, smoking and drinking habits, the physical activity status, and frequency of daily toothbrushing. The independent variables were components of MetS, and the dependent variable was periodontitis. Results: Periodontitis was diagnosed in 37.0% of the participants. The incidence of periodontitis among participants with MetS was 47.9%. The incidences of periodontitis among participants with three, four, and five components of MetS were 44.8%, 50.0%, and 56.2%, respectively. The odds ratio (OR) for periodontitis among participants with MetS was 1.43 (95% confidence interval [CI]: 1.27-1.61). The participants with three, four, and five components of MetS showed a significantly higher OR for periodontitis than those with no components of MetS (three components, OR=1.18, 95% CI: 1.02-1.36; four components, OR=1.34, 95% CI: 1.14-1.59; five components, OR=1.68, 95% CI: 1.29-2.20). Conclusions: A higher number of components of MetS augments the OR of periodontitis.
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Abstract : Objectives: The purpose of this study was to investigate changes in the composition of artificial cariogenic biofilms using a Streptococcus mutans biofilm model over a period of time. Methods: We analyzed the dry weight, colony forming unit (CFU) number, extracellular polysaccharide (EPS) biovolume, and acid production rate of S. mutans biofilms formed on saliva-coated hydroxyapatite discs after 26 h, 50 h, 74 h, 98 h, 171 h, and 195 h. In addition, we performed a laser scanning confocal fluorescence microscopy to determine the bacterial volume, EPS biovolume, and biofilm thickness. We calculated the biofilm density using dry weight and EPS biovolume. Results: Over a period of time, there was no change in the CFU number and acid production rate of S. mutans biofilms, but there was an increase in the dry weight and EPS biovolume of S. mutans biofilms. The bacterial volume, EPS biovolume, and biofilm thickness only increased in the 50-h-old biofilm; however, no change was observed in 50-195-h-old biofilms. In addition, an increase in the biofilm density was observed over time. Conclusions: These results suggest that the acid production ability of cariogenic biofilms does not change, but the biofilm density increases over time. However, due to scientific information, further research needs to be conducted in the field of dentistry to get further insights on the progression of cariogenic biofilms over time.
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Abstract : Objectives: The community water fluoridation program was implemented in 1998 in Jinju city. The aimof the present study was to evaluate the effect of this 17-year community water fluoridation program oncaries reduction in permanent teeth. Methods: Evaluation surveys were conducted in 2015 on subjects aged 8, 10, 12, and 15 years in Jinjucity. The examined dental data were compared with that of subjects of the same age groups living in themedium-sized cities from the 6th Korea National Health and Nutrition Examination Survey (KNHANES)(2013-2015). The total number of subjects was 1,026 in Jinju city and 453 in the control group. Theodds ratio of caries experience rate and untreated tooth rate on permanent teeth in Jinju city comparedto control group was estimated based on the differences in DMF and untreated teeth rates after adjusting for gender, age, and mean number of fissure-sealed teeth. The effect of community water fluoridation program on caries reduction in permanent teeth was estimated by the differences in adjusted DMFTscores between the program and control groups. Results: The odds ratio of caries experience rate and untreated tooth rate on permanent teeth in Jinjucity compared to control group was estimated as 0.501 and 0.178, respectively. The effect of community water fluoridation program on caries reduction in permanent teeth was estimated as 40.0%. Conclusions: These results suggested that the effect of community water fluoridation program on caries reduction in permanent teeth in Jinju city was so high that similar programs should be developed inother regions in Korea.
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Abstract : Objectives: The purpose of this study was to investigate the correlation of periodontitis with metabolic syndromes and menopause status.Methods: The 2013 Korea National Health and Nutrition Examination Survey data of 645 postmenopausal and 663 premenopausal women were analyzed using the Pearson’s chi-squared test and multiple regression analysis with the Statistical Package for the Social Sciences (PASW statistics) software version 21.0. Metabolic syndromes and community periodontal index (CPI) were analyzed. Results: CPI 3, CPI 4 (P
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Abstract : Objectives: To explore changes in self-reported oral health in middle-aged Koreans over a period of 9 years.Methods: This study design was a cross-sectional analysis. This study analyzed the data of 18,845 middle-aged (45-64 years) subjects who participated in 4-6th Korea National Health and Nutrition Examination Surveys (KNHANES). A complex-sample chi-square test was used to analyze self-reported poor oral health according to sex, household income, and education. A complex-sample logistic regression analysis was used to identify the changes in the factors. SPSS 23.0 and the R ver. 3.5.1 statistical package were used for the analyses.Results: Poor oral health have been decreased by 5.3% over the 9-year period. Middle-aged men were more likely to report their oral health as worse than women. The lower income and education groups reported their oral health as poor compared to the higher income and education groups. The factors affecting self-reported poor oral health over the 9-year period were sex, income, and education.Conclusions: More than half of the aged population reported their oral health as poor. Oral health policies should be established for the aged population, including the middle-aged population, for long-term plans.
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Abstract : Objectives: This study was conducted to investigate the awareness of the students currently attending dental colleges/schools in Seoul regarding the scope of work done by a dental hygienist (DH) and a chair-side dental assistant (DA). Methods: A direct questionnaire survey was conducted among 950 students who currently attend dental colleges/schools in Seoul. We were able to use a total of 458 samples for final analysis after excluding inappropriate ones. The contents of this structuralized survey included the obligation of proper name badge use for dental health care personnel, the legal work scopes of a DH and a DA in accordance with the revised execution of the ‘Legal Acts on Medical Technicians’, and the inclusion/exclusion of such contents from dental colleges/schools curricula. The results were statistically analyzed via the IBM SPSS Statistics 25.0 software. Results: Many subjects were aware of the difference in scope of work performed by a DH and a DA (P
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Ji-Eun Jeon, Se-Hwan Jung, Dong-Hun Han, Sae-Rom Lee, Jae-In Ryu
Journal of Korean Academy of Oral Health 2020; 44(1): 20-25
J Korean Acad Oral Health 2020; 44(3): 166-172
J Korean Acad Oral Health 2020; 44(3): 151-157
Boo-Deok Jo, Dong-Kie Kim, Byoung-Jin Lee
Journal of Korean Academy of Oral Health 2015; 39(1): 25-36
Min-Jeong Cho, Eun-Kyung Jung, Sang-Sook Lee, Youn-Hee Choi, Keun-Bae Song
Journal of Korean Academy of Oral Health 2015; 39(3): 214-219
Nam-In Cho, So-Young Park, Heung-Soo Lee, Hyo-Won Oh
Journal of Korean Academy of Oral Health 2013; 37(1): 16-24
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