JKAOH Journal of Korean Academy of Oral Health

ISSN(Print) 1225-388X ISSN(Online) 2093-7784


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Original Article

Journal of Korean Academy of Oral Health 2015; 39(4): 267-272

Published online December 30, 2015 https://doi.org/10.11149/jkaoh.2015.39.4.267

Copyright © Journal of Korean Academy of Oral Health.

Efficacy of dentifrices containing policresulen in controlling dental plaque and gingivitis formation

Bo-Ra Kim1, Hae-Youn Ko1, Sun-Young Han2, Hee Eun Kim3, Eun-Ha Jung1, A-Ram You4, Won-Ho Ha4, Ho-Keun Kwon5, Baek-Il Kim1

1Department of Preventive Dentistry and Public Oral Health, BK21 PLUS Project, Oral Science Research Institute, Yonsei University College of Dentistry, Seoul, 2Department of Dental Hygiene, Wonju College of Medicine, Yonsei University, Wonju, 3Department of Dental Hygiene, College of Health Science, Gachon University, Incheon, 4LG Household & Health Care Research Park, Daejeon, 5Department of Preventive Dentistry and Public Oral Health, Yonsei University College of Dentistry, Seoul, Korea

Received: October 1, 2015; Revised: November 10, 2015; Accepted: December 7, 2015


Objectives: This clinical study aimed to investigate if dentifrices containing policresulen would help to control dental plaque and gingivitis. Methods: Seventy-eight eligible adults participated in this double-blind and randomized clinical study after an initial oral examination, calculus removal, and tooth prophylaxis. Two weeks after the procedure, the participants were assigned to three groups using the following dentifrices: (1) a dentifrice containing 0.22% NaF (control group); (2) a dentifrice containing 0.22% NaF and 100 ppm policresulen (policresulen group); and (3) a dentifrice containing 0.22% NaF, 100 ppm policresulen, and 1.00% bamboo salt (policresulen/bamboo group). The participants used only the provided dentifrice (for 1 min, twice a day, over 8 weeks) when brushing their teeth and followed their normal brushing habits. Dental plaque accumulation and gingivitis measurements were conducted using the Turesky modification of the Quigley- Hein plaque index (PI), the Löe and Silness gingival index (GI), and the percent bleeding on probing (%BOP) to obtain baseline data and 4- and 8-week data after grouping. Results: A total of 73 participants aged 35.92±11.46 years (mean±SD) completed the study. The results after 8 weeks demonstrated statistically significant group-by-time interactions for PI, GI, and %BOP (P<0.001). The PI observed in the control groups increased over time up to 6%, while that observed in the dentifrice groups containing policresulen decreased by 5% (P<0.001). For GI and %BOP, the control group exhibited significantly higher values after 8 weeks, while the policresulen and the policresulen/ bamboo groups revealed similar index values as the baseline after 4 and 8 weeks. The changes in all indices were significantly different between the control and the two experimental groups. There were no significant differences in the results obtained from the policresulen/bamboo group and the results obtained from the policresulen group. Conclusions: Use of dentifrices containing policresulen over 8 weeks demonstrated anti-plaque and anti-gingivitis efficacy compared to a control dentifrice.

Keywords: Clinical trial, Dental plaque index, Dentifrices, Gingival hemorrhage, Gingivitis