JKAOH Journal of Korean Academy of Oral Health

ISSN(Print) 1225-388X ISSN(Online) 2093-7784

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  • Original Article 2020-12-30

    The effect of bile acids on Porphyromonas gingivalis lipopolysaccharide-induced inflammatory response

    JI-A PARK

    Abstract : Objectives: In this study, I aimed to evaluate the inhibitory effect of bile acids on the inflammatory response and osteoclastogenesis in RAW 264.7 cells activated through lipopolysaccharide (LPS) and receptor activator of nuclear factor-κB ligand (RANKL) of the periodontal pathogen Porphyromonas gingivalis.Methods: Myelomonocytic RAW 264.7 cells were activated through P. gingivalis LPS to induce inflammatory response, and were treated with three bile acids, including taurodeoxycholate, taurocholate, and glycocholate at different concentrations. The cytotoxicity of bile acids was assessed through the MTT assay. To evaluate the inhibitory effect of bile acids on inflammatory response, the induction levels of the pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α were measured using ELISA 12 h after the treatment. Additionally, after activating the cells with RANKL to promote osteoclastogenesis, we examined whether bile acids suppressed osteoclast differentiation using the tartrate-resistant acid phosphatase staining.Results: In the cell viability test, taurodeoxycholate and taurocholate did not exhibit any cytotoxic effect on RAW 264.7 cells at concentrations equal to or less than 200 µM, and glycocholate was non-cytotoxic until the maximal concentration (4,000 µM). All the three bile acids exhibited an inhibitory effect on inflammatory response, as the production levels of pro-inflammatory cytokines, including IL-6 and TNF-α, decreased with an increase in the concentration of the three bile acids in a dose-dependent manner. The expression of IL-6 reduced remarkably upon treatment with taurodeoxycholate and glycocholate (P<0.001), while the expression of TNF-α decreased slightly upon treatment with glycocholate (P<0.05). Moreover, only glycocholate at a concentration of 1,000 µM suppressed osteoclast differentiation of RAW 264.7 cells (P<0.001), while taurodeoxycholate and taurocholate did not exhibit an inhibitory effect on osteoclastogenesis.Conclusions: Here, I showed that all the three bile acids (taurodeoxycholate, taurocholate, and glycocholate) inhibited P. gingivalis LPS-induced inflammatory response, and glycocholate partially suppressed RANKL-mediated osteoclastogenesis in RAW 264.7 cells.

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  • Original Article 2021-03-30

    Association between periodontal disease and hypertension using propensity score matching: results from the seventh (2016-2018) Korea National Health and Nutrition Examination Surve

    Eun Young Park , Eun-kyong Kim

    Abstract : Objectives: This study aimed to show a correlation between periodontal disease and hypertension. Methods: This study analyzed data of 6794 adults over 19 years based on results from the Korea National Health and Nutrition Examination Survey for the period 2016-2018. Complex sample analysis and propensity score matching analysis methods were conducted to determine whether a correlation between periodontal disease and hypertension existed. Results: Results of the complex sample logistic regression analysis were: OR=1.4 (95% CI:1.23- 1.58). However, the result of the conditional logistic regression analysis after propensity score matching yielded no correlation between periodontitis and hypertension (OR=1.03 (95% CI:0.92- 1.16)). Conclusions: It is difficult to conclude that a significant correlation exists between hypertension and periodontal disease, and further studies need to be performed to assess a significant correlation.

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  • Original Article 2020-12-30

    Analysis of the distribution and association of periodontal disease-causing bacteria in saliva according to the severity of periodontitis in the elderly in some communities

    Sukmin Lee , Yun-Sook Jung , Keun-Bae Song , Youn-Hee Choi

    Abstract : Objectives: Periodontitis-causing microorganisms and their virulence factors can provoke periodontal destruction in the host. This study was aimed at evaluating the distribution of periodontal disease and its relationship with 11 periodontal disease-causing bacteria in the elderly.Methods: Individuals aged 60 years or above were recruited after obtaining informed consent. The clinical attachment loss was measured at studied sites to determine the severity of periodontitis. Further, the stimulated salivary samples were collected and analyzed with real-time polymerase chain reaction to detect 11 strains of periodontitis-causing bacteria.Results: The severity of periodontal disease was proportional to the amount of periodontal disease-causing bacteria. Porphyromonas gingivalis in the red complex increased from 6.60±5.50 in stage 1 to 5.36±5.39 in stage 2 and 7.19±5.56 in stage 3 (P=0.003). Tannerella forsythia increased from 6.54±4.60 in stage 1 to 7.44±4.56 in stage 2 and 8.49±4.70 in stage 3 (P=0.007).Conclusions: The presence of complex bacterial groups and their number of strains were high in participants with severe periodontitis. Controlling periodontitis-related bacteria is important for periodontal health in the elderly.

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  • Original Article 2020-09-30

    Risk factors related to periodontal health of adolescents

    Ji-Soo Kim , Se-Yeon Kim , Min-Ji Byon , Eun-Joo Jun , Seung-Hwa Jeong , Jin-Bom Kim

    Abstract : Objectives: The purpose of this study was to investigate the risk factors related to periodontal health in middle school and high school adolescents. Methods: This study was conducted using data from the Sixth Korean National Health and Nutrition Examination Survey (KNHANES, 2013-2015). Among the 22,948 participants in the Sixth KNHANES, 1,222 participants (aged 12-18 years) who completed the systemic and oral health examinations and questionnaires were included in this study. Independent variables related to demographic socioeconomic status and oral health-related behaviors were the following: age, gender, household income, frequency of daily toothbrushing, smoking, alcohol drinking, annual dental visit, and periodontal treatment. The dependent variables were the prevalence of gingival bleeding or calculus and the number of sextants with gingival bleeding or calculus.. Results: Among the total participants, 34.1% were diagnosed with prevalence of gingival bleeding or calculus, and periodontal health was found to be at its worst at 17 years of age (41.6% of participants). Moreover, household income, alcohol drinking, annual dental visits, and frequency of daily toothbrushing were related to prevalence and the number of sextants with gingival bleeding or calculus. The adjusted odds ratio (aOR) for prevalence of gingival bleeding or calculus by alcohol consumption, toothbrushing less than twice per day, and number of DMFT were 5.00 (95% CI: 2.24- 11.18), 2.21 (95% CI: 1.21-4.04), and 1.09 (95% CI: 1.02-1.17), respectively. Conclusions: To prevent periodontal disease among adolescents, it is necessary to improve oral health-related behavior and its associated factors and continuous oral health education.

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  • Original Article 2020-12-30

    Preventive effect of a 18-year water fluoridation program for dental caries in a rural area of Korea

    Ji-Soo Kim , Min-Ji Byon , Eun-Joo Jun , Seung-Hwa Jeong , Jin-Bom Kim

    Abstract : Objectives: The water fluoridation program in Hapcheon township area has been implemented since 2000. This study aimed to evaluate the caries-preventive effect of water fluoridation on permanent teeth after implementation of an 18-year community water fluoridation program in a suburban area.Methods: A survey was conducted in 2018 with 359 subjects, aged 8, 10, and 12 years, residing in the Hapcheon township area. In this prospective cohort study, the data on caries prevalence obtained from 671 subjects, aged 8, 10, and 12 years, in 2000, when the community water fluoridation program was initiated in the township, were used as a cohort to evaluate the caries-preventive effect after 18 years. The caries-preventive effect of community water fluoridation on permanent teeth was estimated by comparison of the adjusted DMFT scores between the program and the control group, and between the pre- and post-program data after 18 years. The confounding factor, mean number of fissure-sealed teeth, was adjusted to estimate the caries-preventive effect of fluoridation on permanent teeth.Results: Based on the results of the surveys conducted in Hapcheon-eup in 2000 and 2018, the mean number of fissure-sealed permanent teeth was 2.24 in 2000 and 1.38 in 2018. The mean DMFT scores of subjects aged 8, 10, and 12 years in 2018, adjusted for fissure-sealed permanent teeth in the fluoridated area, were significantly lower than those reported by the 2018 Korea National Children’s Oral Health Survey. In addition, the mean values of the adjusted DMFT scores of subjects aged 8, 10, and 12 years in 2018, after the 18-year fluoridation program, were significantly lower than those reported in 2000, the year the fluoridation program was initiated.Conclusions: Community water fluoridation has a high caries-reducing effect; thus, the reintroduction of water fluoridation program is desirable to prevent dental caries.

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  • Original Article 2020-12-30

    Inhibitory effect of the probiotic bacteria, Weissella cibaria CMU on halitosis: a randomized placebo-controlled study

    Da-Hui Kim , Mi-Sun Kang , Ji-Eun Yeu , Myung-Gu Lee , Ja-Won Cho

    Abstract : Objectives: Previous studies have suggested that the lactic acid bacterium, Weissella cibaria CMU has beneficial effects on halitosis, but its precise effects have not been evaluated in human subjects. We evaluated the efficacy and safety of W. cibaria CMU for reducing halitosis in adults (20-70 years old) whose exhibited volatile sulfur compound (VSC) concentrations exceeded 0.015 ng/mL and who scored ≥2 points in a halitosis sensory evaluation test.Methods: A total of 60 participants were assigned to an experimental group (treated with W. cibaria CMU) and a control group (placebo). In total, 58 out of 60 participants (experimental group, 29; control group, 29) were ultimately included in gas chromatography (OralChroma) analyses of VSC concentrations and halitosis sensory evaluation tests.Results: We found that the VSC concentration decreased by 0.030±0.062 ng/ml in the experimental group after 8 weeks (P=0.0138) and increased by 0.005±0.124 ng/ml in the control group (P=0.8198). However, the difference between groups was not statistically significant (P>0.05). In a sensory evaluation test, a significantly lower score was obtained for the experimental group than for the control group.Conclusions: Overall, VSC concentrations and sensory evaluation scores were lower in the experimental group than in the control group, but only the latter was statistically significant. Thus, we conclude that W. cibaria CMU is involved in the reduction of halitosis.

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  • Original Article 2021-03-30

    A study on the influencing factors of oral health-related behaviors of the elderly in elderly welfare facilities on oral health-related quality of life

    Byung Ik Yang , Ji-A Park , Jae-Young Lee , Bo-Hyoung Jin

    Abstract : Objectives: In order to understand the factors that influence the oral health-related quality of life of older adults, we investigated the quality of life, oral health status, and oral health behavior of older adults in a metropolitan city in Korea. Methods: Data were collected from October 2019 to March 2020, after approval was obtained from the authors’ institutional review board. Oral examinations were administered and a structured questionnaire was distributed to 150 older adults at a public nursing home. Data on sociodemographic factors, oral health behaviors, general health questions, and oral health-related quality of life (assessed with the Oral Health Impact Profile-14 [OHIP-14]) were collected with the questionnaire. To assess the general health condition of the participants, grip strength and upper arm and calf circumference were measured. Multiple logistic regression analysis was used to determine the correlation between oral health-related quality of life and other variables. Results: Whether brushing was performed, the number of remaining teeth, and the presence of periodontal disease were found to correlate with OHIP-14 scores (P<0.05). Oral Health Impact Profile-14 scores and sociodemographic factors in older adults through multiple logistic regression analyses with general health, oral health habits and conditions, and need for assistance with daily oral health care. Correlations between OHIP-14 scores and general health variables, such as thigh circumference and grip strength, revealed a low oral health-related quality of life in participants who needed help during brushing (P<0.05). Conclusions: Results of the study confirmed a relationship between OHIP-14 scores and oral health and habits among older adults in public nursing homes with socioeconomic status, and general health, and oral health, and each variable affects the relationship. Further analysis and additional epidemiological studies are needed to understand the interrelationships.

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  • Original Article 2020-12-30

    Inhibitory effect of mastic oil on Streptococcus mutans growth

    Doh-Hyun Lee , Ji-Hye Kim , Sagn-Uk Im , Yun-Sook Jung , Youn-Hee Choi , Keun-Bae Song

    Abstract : Objectives: The aim of this study was to examine the antibacterial effect of mastic oil on a representative caries-inducing bacterium, Streptococcus mutans.Methods: S. mutans UA159 was maintained in a BHI medium containing 0.1% sugar at 37℃ and 10% CO2. Strains were treated with six different concentrations of mastic oil (0, 0.1, 0.2, 0.3, 0.4, 0.5%). After incubation for 16 h, the antibacterial effect was evaluated by measuring the optical density (OD) and observing the colony-forming unit. A microtiter plate assay was performed to analyze the anti-adhesion ability of mastic oil on S. mutans.Results: More than 0.1% of mastic oil inhibited the growth of S. mutans. In addition, 0.4% mastic oil exterminated S. mutans. Mastic oil induced an anti-adhesive ability in S. mutans.Conclusions: These results suggest that mastic oil may be used as a preventive measure against dental caries.

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  • Original Article 2020-12-30

    Factors related to CPR performance ability of dental hygenists working in dental hospitals

    Eun-Young Choi , Choong-Ho Choi

    Abstract : Objectives: In this study, we aimed to investigate the cardiopulmonary resuscitation (CPR)-related knowledge, attitude, and performance among dental hygienists working in the hospitals. We believe that it is important to develop CPR education programs that would enable dental hygienists to offer accurate and timely aid in emergency situations.Methods: From June 20 to August 20, 2019, 220 dental hygienists at seven selected dental hospitals located in Gwangju Metropolitan City and Jeollanam-do, South Korea were requested to fill a questionnaire as part of a survey.The data regarding the general characteristics, CPR-related characteristics, and CPR-related knowledge, approach, and performance were collected, and analyzed using independent t-tests, one-way analysis of variance (ANOVA), Pearson’s correlation coefficient, and simple regression analysis using the SPSS Windows ver. 25.0.Results: Correlation analysis revealed that high CPR-related knowledge and a more positive approach towards CPR are both associated with high confidence in performing CPR (r=0.37, r=0.415, r=0.605). Furthermore, factors, such as high CPR-related knowledge, positive attitude towards CPR, knowledge regarding the location of automated external defibrillators (AEDs) in the hospital, and AED training experience significantly affects the CPR-related performance.Conclusions: Therefore, it is important to develop systematic and beneficial educational programs and provide and update educational material regularly in dental hospitals with an aim to improve CPR-related knowledge and attitude among the dental hygienists.

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  • Editorial 2020-09-30

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June, 2022
Vol.46 No.2

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JKAOH Journal of Korean Academy of Oral Health
ISSN(Print) 1225-388X ISSN(Online) 2093-7784