JKAOH Journal of Korean Academy of Oral Health

ISSN(Print) 1225-388X ISSN(Online) 2093-7784

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  • Original Article 2019-06-30

    Effect of apoptosis on G361 cells by Cimicifuga rhizoma extract

    Byul Bo Ra Choi, Gyoo Cheon Kim, Jin Woo Hong, Sang Rye Park

    Abstract : Objectives: To investigate whether the cytotoxic effect of Cimicifuga rhizoma extract is associated with cell death in the human keratinocyte (HaCaT) and human melanoma cell lines (G361). Methods: Apoptosis induced by Cimicifuga rhizoma extract was confirmed by water-soluble tetrazolium salts-1 (WST-1) assay, immunocytochemistry, and western blot. Additionally, the release of cytochrome c and apoptosis-inducing factor (AIF) was visualized by confocal laser scanning microscopy.Results: The results showed that Cimicifuga rhizoma extract significantly reduced the viability of G361 cells with half-maximal inhibitory concentration (IC 50) of 200 μg/ml, and the apoptotic process was found to occur via the activation of caspase-3 and caspase-9 pathways. Besides, the release of cytochrome c and AIF was also detected. Conclusions: This study suggests that Cimicifuga rhizoma extract causes apoptosis of human melanoma cells through the intrinsic apoptotic pathway.

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  • Original Article 2020-12-30

    The effect of socio-psychological trait on the oral health related quality of life among college students

    Byung-Su Kim , Jae-Gyu Jeon , Hyo-Won Oh

    Abstract : Objectives: The purpose of this study was to examine the association between oral health-related quality of life and adult attachment type among college students.Methods: A total of 557 self-administered questionnaires were collected from undergraduates in Jeonbuk. Data were analyzed using SPSS 22.0. The results were analyzed using t-tests, analyses of variance, Duncan’s multiple range tests, correlation analyses, and multiple regression analyses.Results: The results of this study showed that sex and age were significant factors according to the analysis of the oral health-related quality of life in terms of general characteristics. The variable that had the greatest effect on the oral health-related quality of life was attachment anxiety, followed by age, sex, and attachment avoidance.Conclusions: Education and counseling to promote safety of adult attachment will improve the oral health-related quality of life for college students.

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  • Original Article 2019-06-30

    Caries reduction effect of permanent teeth from community water fluoridation program for 17 years in Jinju city

    Tae-Young Ok, Yong-Bong Kwon, Ji-Soo Kim, Se-Yeon Kim, Jung-Ha Lee, Han-Na Kim, Jin-Bom Kim

    Abstract : Objectives: The community water fluoridation program was implemented in 1998 in Jinju city. The aimof the present study was to evaluate the effect of this 17-year community water fluoridation program oncaries reduction in permanent teeth. Methods: Evaluation surveys were conducted in 2015 on subjects aged 8, 10, 12, and 15 years in Jinjucity. The examined dental data were compared with that of subjects of the same age groups living in themedium-sized cities from the 6th Korea National Health and Nutrition Examination Survey (KNHANES)(2013-2015). The total number of subjects was 1,026 in Jinju city and 453 in the control group. Theodds ratio of caries experience rate and untreated tooth rate on permanent teeth in Jinju city comparedto control group was estimated based on the differences in DMF and untreated teeth rates after adjusting for gender, age, and mean number of fissure-sealed teeth. The effect of community water fluoridation program on caries reduction in permanent teeth was estimated by the differences in adjusted DMFTscores between the program and control groups. Results: The odds ratio of caries experience rate and untreated tooth rate on permanent teeth in Jinjucity compared to control group was estimated as 0.501 and 0.178, respectively. The effect of community water fluoridation program on caries reduction in permanent teeth was estimated as 40.0%. Conclusions: These results suggested that the effect of community water fluoridation program on caries reduction in permanent teeth in Jinju city was so high that similar programs should be developed inother regions in Korea.

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  • Original Article 2020-12-30

    Inhibitory effect of the probiotic bacteria, Weissella cibaria CMU on halitosis: a randomized placebo-controlled study

    Da-Hui Kim , Mi-Sun Kang , Ji-Eun Yeu , Myung-Gu Lee , Ja-Won Cho

    Abstract : Objectives: Previous studies have suggested that the lactic acid bacterium, Weissella cibaria CMU has beneficial effects on halitosis, but its precise effects have not been evaluated in human subjects. We evaluated the efficacy and safety of W. cibaria CMU for reducing halitosis in adults (20-70 years old) whose exhibited volatile sulfur compound (VSC) concentrations exceeded 0.015 ng/mL and who scored ≥2 points in a halitosis sensory evaluation test.Methods: A total of 60 participants were assigned to an experimental group (treated with W. cibaria CMU) and a control group (placebo). In total, 58 out of 60 participants (experimental group, 29; control group, 29) were ultimately included in gas chromatography (OralChroma) analyses of VSC concentrations and halitosis sensory evaluation tests.Results: We found that the VSC concentration decreased by 0.030±0.062 ng/ml in the experimental group after 8 weeks (P=0.0138) and increased by 0.005±0.124 ng/ml in the control group (P=0.8198). However, the difference between groups was not statistically significant (P>0.05). In a sensory evaluation test, a significantly lower score was obtained for the experimental group than for the control group.Conclusions: Overall, VSC concentrations and sensory evaluation scores were lower in the experimental group than in the control group, but only the latter was statistically significant. Thus, we conclude that W. cibaria CMU is involved in the reduction of halitosis.

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  • Original Article 2019-12-30

    Elucidating the relationship of gingivitis and dental calculus with the periodontal health of 12-year-old children

    Jung-Ha Lee, Se-Yeon Kim, Ji-Soo Kim, Min-Ji Byon, Eun-Joo Jun, Han-Na Kim, Jin-Bom Kim

    Abstract : Objectives: This study aimed to investigate factors related to the periodontal health of 12-year-old children. Methods: In 2015, the Korean Children's Oral Health Survey from the Ministry of Health & Social Welfare conducted a nationwide representative sample comprised of 23,702 12-year-old children. The calibration-trained dentists examined the gingivitis and dental calculus of the children taking into consideration of the Löe and Silness gingival index to diagnose gingivitis with a modified gingivitis scale. We used questionnaires to collect data from the children on dental treatments, the experience of dental pain and gingival bleeding, self-perceived oral health, and oral health behaviors. Data were analyzed using a complex samples Chi-square test, general linear model, and logistic regression. Significance was determined at P

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  • Original Article 2020-12-30

    Studies on inhibition of gingival fibroblast proliferation by nicotine concentration

    Kang-Uk Han , Cheon-Hee Lee , Joon-Haeng Lee , Yeol-Mae Jeon , Hyun-Jun Yoo

    Abstract : Objectives: To investigate the effect of nicotine on the healing of an oral cavity wound, high and low concentrations of nicotine were administered on human gingival fibroblasts.Methods: Nicotine at concentrations of 0.1, 1, 5, and 10 mM were administered to gingival fibroblasts to evaluate the survival capability of the cells. Nicotine at 0.1 mM, a nonapoptotic concentration, was administered to evaluate apoptosis using Annexin V-FITC/Propidium Iodide cell staining. Nicotine at 1, 10, and 100 µM were administered to measure the expression of inflammatory cytokines, which was measured by RT-PCR and ELISA. FGF was treated with an additional 1, 10, or 100 µM of nicotine to evaluate cell proliferation and wound healing.Results: As the concentration of nicotine increased (0.1, 1, 5, and 10 mM), the survival capability of the cells reduced. When cells were exposed to low nicotine concentration (0.1 mM) for 24 h, apoptosis occurred. Moreover, if the cell was exposed for 48 h, cell apoptosis occurred with necrosis. As the concentration of nicotine increased (1, 10, and 100 µM), more inflammatory cytokines were expressed. When EC LPS and TF LPS were combined with a low concentration of nicotine (1 and 10 mM), the expression of inflammatory cytokines was suppressed. The FGF level decreased as the nicotine concentration increased (1, 10, and 100 µM).Conclusions: Nicotine interferes with the wound healing process of gingival fibroblasts. To maintain the wound healing process after a surgery or dental procedure, cessation of smoking is recommended.

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  • Original Article 2019-12-30

    Possibility of predicting missing teeth using deep learning: a pilot study

    Seon-Jip Kim, Dohyoung Rim, Jeong Uk Heo, Hyun-Jae Cho

    Abstract : Objectives: The primary objective of this study was to determine if the number of missing teeth could be predicted by oral disease pathogens, and the secondary objective was to assess whether deep learning is a better way of predicting the number of missing teeth than multivariable linear regression (MLR). Methods: Data were collected through review of patient's initial medical records. A total of 960 participants were cross-sectionally surveyed. MLR analysis was performed to assess the relationship between the number of missing teeth and the results of real-time PCR assay (done for quantification of 11 oral disease pathogens). A convolutional neural network (CNN) was used as the deep learning model and compared with MLR models. Each model was performed five times to generate an average accuracy rate and mean square error (MSE). The accuracy of predicting the number of missing teeth was evaluated and compared between the CNN and MLR methods. Results: Model 1 had the demographic information necessary for the prediction of periodontal diseases in addition to the red and the orange complex bacteria that are highly predominant in oral diseases. The accuracy of the convolutional neural network in this model was 65.0%. However, applying Model 4, which added yellow complex bacteria to the total bacterial load, increased the expected extractions of dental caries to 70.2%. On the other hand, the accuracy of the MLR was about 50.0% in all models. The mean square error of the CNN was considerably smaller than that of the MLR, resulting in better predictability. Conclusions: Oral disease pathogens can be used as a predictor of missing teeth and deep learning can be a more accurate analysis method to predict the number of missing teeth as compared to MLR.

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  • Original Article 2019-09-30

    Association between components of metabolic syndrome and periodontitis in Korean adults aged 35-79 years

    Ji-Soo Kim, Se-Yeon Kim, Min-Ji Byon, Jung-Ha Lee, Seung-Hwa Jeong, Jin-Bom Kim

    Abstract : Objectives: The purpose of this study was to investigate the association between the components of metabolic syndrome (MetS) (waist circumference, hyperglycemia, hypertriglyceridemia, low levels of high-density lipoprotein cholesterol, and hypertension) and periodontitis in Korean adults aged 35-79 years. Methods: In this study, data from the Sixth Korean National Health and Nutrition Examination Survey (KNHANES, 2013-2015) were analyzed. Among the 22,948 participants of the Sixth KNHANES, 8,314 participants, who were aged 35-79 years and had completed all systemic and oral health examinations and questionnaires, were included in this study. Confounding variables associated with the demographics and socioeconomic status and systemic and oral health-related behaviors were age, gender, household income, the educational level, smoking and drinking habits, the physical activity status, and frequency of daily toothbrushing. The independent variables were components of MetS, and the dependent variable was periodontitis. Results: Periodontitis was diagnosed in 37.0% of the participants. The incidence of periodontitis among participants with MetS was 47.9%. The incidences of periodontitis among participants with three, four, and five components of MetS were 44.8%, 50.0%, and 56.2%, respectively. The odds ratio (OR) for periodontitis among participants with MetS was 1.43 (95% confidence interval [CI]: 1.27-1.61). The participants with three, four, and five components of MetS showed a significantly higher OR for periodontitis than those with no components of MetS (three components, OR=1.18, 95% CI: 1.02-1.36; four components, OR=1.34, 95% CI: 1.14-1.59; five components, OR=1.68, 95% CI: 1.29-2.20). Conclusions: A higher number of components of MetS augments the OR of periodontitis.

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  • Editorial 2020-12-30

  • Original Article 2019-09-30

    Impact of incivility experienced by dental hygienists on organizational achievement -as a mediating effect of emotional exhaustion

    Mun Mi Cho, Jin Bom Kim, Hyeon Sook Kwun, Chang Wan Kang, Min Kyung Lee, Jung Won Yun, Ho Jin Jeong, Jung Hwa Lee

    Abstract : Objectives: Workplace incivility is experienced by dental hygienists, who perform a variety of tasks and roles in dentistry. Therefore, to enhance the performance of dental and medical institutions, it is necessary to identify dental hygienists experiencing incivility that affects the organizational performance. Methods: Over a two-month period from May 1 to June 30, 2015, dental hygienists from 30 dental and medical institutions in Busan, the North and South Gyeongsang Provinces, Daegu, Seoul, and the Gyeonggi Province were convenience sampled. Data, from a total of 344 participants, were analyzed using the SPSS and AMOS statistical analysis software. Results: Emotional exhaustion had a partial mediating effect on the relationship between patient incivility and job performance, a full mediating effect in relation to job satisfaction, and a partial mediating effect on the association with turnover intention. Meanwhile, emotional exhaustion had a full mediating effect on the relationships between superior incivility and job performance, as well as turnover intention, while a partial mediating effect in relation to job satisfaction. Conclusions: An in-depth review of interventions that can enable a mutually respectful working environment, and promote a healthy culture among dental hygienists in dental and medical institutions is needed.

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March, 2021
Vol.45 No.1

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JKAOH Journal of Korean Academy of Oral Health
ISSN(Print) 1225-388X ISSN(Online) 2093-7784